Although rapamycin isn’t available on the open market, we do have an opportunity to extend the lifespan of our dogs and cats by making good choices about their food and supplements. Commercial pet food is not always easily digested, and many dogs and cats lack the essential digestive enzymes that allow them to get the full nutritional benefit of their food.

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1 In mammalian T-lymphocytes, Rapamycin blocks the signal transduction pathway initiated by interleukin-2.

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Selectively inhibits mTOR and blocks activation of p70 S6 Kinase (IC₅₀ = 50 pM). Sigma-Aldrich. pricing.

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Mammalian target of rapamycin complex I (mTORC1) signaling is known as a master regulator of aerobic glycolysis [12,13], which is also consistently activated  

In lab experiments, the chemical has significantly lengthened the lifespan of yeasts, worms, fruit flies, and mice. It's currently being tested in pet dogs. If this trial is successful, rapamycin may then be tested in humans. Rapamycin seems to work by inhibiting a protein known as mTOR.